Roswell Park Cancer Institute has been awarded a multimillion dollar grant to find out why young African- American women are more likely to get an aggressive form of breast cancer than young white women.The study, which is the largest to date on breast cancer in African- American women, will involve 5,500 African-American women from four ongoing studies and 5,500 healthy women as a control group.
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The National Cancer Institute awarded $19.5 million to researchers from Roswell Park, the Slone Epidemiology Center at Boston University and the University of North Carolina Lineberger Comprehensive Cancer Center to form a team to undertake the five-year investigation. African-American women under 45 have a five-year survival rate from breast cancer of 76 percent, compared with 88 percent for young white women. Overall, women of European descent are more likely to get breast cancer, but African-American women are more likely to get breast cancer before 45, and are more likely to have an aggressive form that is not as treatable.
The investigation will be the first to develop comprehensive models for contributions of genetic and nongenetic risk factors for breast cancer in African- American women. The goal is to discover genetic, biological, reproductive and behavioral risks for breast cancer subgroups defined by tumor biology and the age at onset of disease. The study will gather together questionnaires, DNA and tumor samples from the four studies, as well as additional information on the study subjects.
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